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ChREBP, the most common form of ChREBP in hepatocytes, binds to the promoter of target genes through a highly conserved sequence called carbohydrate response element (ChoRE), which was reported in the promoter region of Fgf21 in both mice (-74 to -52 bp) and humans (-380 to -366 bp) [57]

[25] Cancer [edit] In response to a report of precancerous changes in the pancreases of rats and organ donors treated with the DPP-4 inhibitor sitagliptin, [26] [27] the US FDA and the European Medicines Agency each undertook independent reviews of all clinical and preclinical data related to the possible association of DPP-4 inhibitors with pancreatic cancer

Disease prevention using whole plant extracts, or isolated compounds from plant (phytochemicals), is gaining more scientific attention worldwide, because it is a cost-effective alternative to orthodox treatment, and the phytochemicals are presumed from anecdotal evidence to be safe, with low toxicity and general acceptance [152,153]

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34, Metal Ions in Biological Systems (Marcel Dekker, Inc., 1996)