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Furthermore, a study has found that methylbarbadenolone (BARD), an antioxidant modulator, could play a renoprotective role through the Nrf2 signaling pathway (Song et al., 2019)

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Nita et al., 2014) and insulin action, indirectly via activation of the renin-angiotensin-aldosterone system (Garg et al., 2011

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Therefore, we can conclude that the inhibition of mitochondrial activity by metformin is probably the driver of the phenotype observed here

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