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That said, individuals with active cancers, untreated endocrine disorders, or insulin resistance should avoid use unless supervised by a qualified healthcare provider

In a randomised phase II trial, the combination of pelareorep with carboplatin/paclitaxel was safe but did not improve PFS in patients with metastatic pancreatic adenocarcinoma (NCT01280058) [123]

Blomgran, R., Desvignes, L., Briken, V

2 JC19 analogs have varying degrees of nsp14 depletion efficiency

van der Stelt M, Fox SH, Hill M, Crossman AR, Petrosino S, Di Marzo V, Brotchie JM (2005) A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinsons disease