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322 Antitumor activity was also observed in HNSCC xenografts with alterations in PIK3CA after treatment with the dual PI3K-mTOR inhibitor PF-5212384, and the activity was promoted by the MEK inhibitor PD-0325901

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The same arrays or different arrays can be used for analysis of characterized polymorphisms.WO 95/11995 also describes sub arrays that are optimized for detection of a variant form of a precharacterized polymorphism

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