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Thus, we identified GSTM2 as an important negative regulator in hepatic steatosis progress

Using distinct HIF-1 antibodies for staining macrophages, dual-positive immunofluorescence for HIF-1 + and CD206 + macrophages was detected in proximity to capillaries (186), indicating that vascular neogenesis in jDM patients is regulated by the VEGF/HIF pathway, inducing HIF-1 and promoting CD206 expression in macrophages, which may lead to hypoxic damage to capillaries in DM patients

Zhou J, Chuang Y, Redding-Ochoa J, Zhang R, Platero AJ, Barrett AH, et al

The other is efflux transporters, which are generally ATP-binding cassette transporters, such as P-glycoprotein and breast cancer resistance protein (BCRP)