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A study in the freshwater bony fish Pelteobagrus fulvidraco found that copper (Cu) exposure could increase the content of intracellular lipids, while zinc (Zn) activation inhibited lipid sequestration induced by Cu exposure

There were no statistically significant differences in the parameters, neither between the experimental and control groups, nor between the initial baseline (T1) and final measurements (T4)

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Notably, NADPH depletion sensitizes fibrosarcoma HT-1080 cells to ferroptosis inducers, indicating that NADPH is negatively associated with ferroptosis sensitivity (48)