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doi: 10.1161/01.cir.98.14.1372

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Moreover, engineered antibodies that induce LepR homodimerization independently of leptin have been shown to exert full agonist activity, suggesting recruitment of two copies of LepR is sufficient for full receptor activation 43

This work was also supported by the project of the Czech Ministry of HealthNV19-09-00578

Neuroprotective efficacy was evidenced by a 62% reduction in the loss of tyrosine hydroxylase+ neurons in the substantia nigra and substantial recovery of striatal dopamine and metabolites