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The lack of efficacy of inhaled GSH in patients with cystic fibrosis could be explained by the high concentrations of the GSH-degrading enzyme -glutamyltransferase present in lung fluids of those patients (116123), and then, the use of precursors of GSH synthesis like NAC and cystine could be more effective in the synthesis of GSH (124)

Khorshidian et al., 2021

However, despite the progress that has been made with the 3D cocultures, preclinical (animal) models, especially the application of mice remain the common experimental system that is currently used to study the pathogenesis of DILI [5254]