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Description

Behavioural and Cognitive Psychotherapy, 1-6

The major phosphorylation sites of AKT1/2/3 are located at Thr308/Thr309/Thr305 in the catalytic domain (phosphorylated by PDK1) and Ser473/Ser474/Ser472 in the regulatory domain (phosphorylated by mTORC2) (46, 48)

We expect that this pathway will be relevant to the physiology and pathophysiology of liver, muscle, adipose, and other highly metabolically active cell types