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The X-ray-derived data of small molecular fragments in complex with TGR used in this study to design the compounds here described are available in the PDB under accession codes 6FTC, 6FMU, 6FMZ, 6FP4, 2X99, 2X8G, 2X8H, 6ZST, 6ZP3, 6ZLP, 6ZLB, 7B02, 7NPX, 2V6O, 6RTJ, 6RTO, 6RTM, and 3H4K

Soon after reaching the sutures, fiber cells degrade all intracellular membrane-bound organelles, including their nuclei, mitochondria, and endoplasmic reticulum

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Syn-Ake is particularly effective for deep, long-established crow's feet where a single neurotransmitter mechanism is insufficient