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With these bioactive forms, the B12 does not need to be converted by your genes/enzymes in order to be available for use by your cells (conversion can be a problem for people with MTR, MTRR, COMT as well as other gene defects)

Supplementing with vitamin B12 lowers homocysteine levels and may improve mood, particularly in response to stress

Research protocols frequently front-load TB-500 with multiple administrations per week during an initial loading period (commonly 4-6 weeks), then shift to a maintenance phase with less frequent administration