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Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]

Nutr Metab (Lond) 13:88

Melatonin inhibits the development of endometriosis by disrupting mitochondrial function and regulating siRNA expression in mouse models (137)

These results suggest that mitochondria may take up melatonin to maintain their function after pinealectomy

doi: 10.3390/ijms22157854 25 ChanAHSchroderK