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HCV-induced oxidative stress by inhibition of Nrf2 triggers autophagy and favors release of viral particles

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Defense mechanisms against free radical-induced oxidative stress involve: (1) preventive mechanisms, (2) repair mechanisms, and (3) antioxidant defenses

Both BA groups showed reduced hepatocyte zonation as demonstrated by lower portal hepatocyte gene signature than nonBA and NL groups (Figure 1B)

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