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Pharmacology of paracetamol Deranged Physiology glutathione acetaminophen toxicity alcohol nadph metabolism. Acetaminophen is metabolized primarily by The conjugation of acetaminophen by Proper paracetamol use is not problematic, but hepatotoxicity may result from overdose Drugs & Therapy Perspectives Springer Nature Link A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 13: DRUG OVERDOSE: PARACETAMOL AND SALICYLATE Nurse Key
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