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261 Benzodiazepines are also well known to cause tolerance (the need for increasing doses to experience the same effect) and addiction with potentially life-threatening consequences

Studies investigating muscle dysfunction in chronic fatigue syndrome have shown that patients exhibit an overreliance on this anaerobic metabolism even during low-level, everyday activities, leading to prolonged intramuscular acidosis and a slowed ability to clear protons from the tissue

Optional B vitamins (B12, B6, B5): support energy metabolism and lipotropic pathways.

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