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doi: 10.3389/fnins.2026.1746678 Received 14 November 2025 Revised 27 March 2026 Accepted 31 March 2026 Published 30 April 2026 Volume 20 - 2026 Edited by Jrg Felder, Helmholtz Association of German Research Centres (HZ), Germany Reviewed by Catarina Rua, Antaros Medical, Sweden Frances Mc Hugh, Auckland City Hospital, New Zealand Updates Copyright 2026 Keith, Woodward, McLennan, Hopkins, Trinder, Allwood-Spiers, Alakandy, OKane, Grivas, Molinari, OLeary, Gorrie, Razvi, Williamson, Chalmers, Stewart, Muir, Porter and Fullerton

for example, TNF- has a significant proviral replicative effect on JC polyomavirus in neuronal tumour cells 40 and has significant antiviral effects on cytomegalovirus CSFV 41 , CMV 42 and herpesvirus type I (HSV-1) 43