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Unger RH, Clark GO, Scherer PE, Orci L

From Laboratory Research to Commercial Products The journey from laboratory research to market-ready products has involved significant effort and innovative ideas

Interestingly, the presence of proinflammatory cytokines can further induce the level of expression of NK-1R by colonic epithelial cells suggesting that positive feedback loops may exist to potentiate the pro-inflammatory actions of substance P in the gastrointestinal tract (Goode et al., 2003)