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Narcoleptics may not be able to experience the amount of restorative deep sleep that healthy people experience due to abnormal REM regulation they are not "oversleeping." Narcoleptics typically have higher REM sleep density than non-narcoleptics, but also experience more REM sleep without atonia

Evening timing may also improve sleep quality in some patients through choline's role as a precursor to acetylcholine, the neurotransmitter involved in REM sleep regulation

NADPH is also required for the anabolic pathways of fatty-acid and cholesterol synthesis

must be factored into the analyses to isolate the effects of supplemental leucine as a stand-alone, or if taken with other branched-chain amino acids (BCAAs)

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