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Description

Native IGF-1 has a frustrating pharmacokinetic limitation: it binds tightly to a family of IGF binding proteins (IGFBPs, particularly IGFBP-3) that sequester it in circulation and keep its free half-life to roughly 15-20 minutes

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CJC-1295 amplifies GH release via GHRH receptor (GHRH-R) agonism a Gs/cAMP/PKA cascade that drives both GH exocytosis and GH gene transcription

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