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Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)

It is known for producing peptides at multi-kilogram scale using both solid-phase and solution-phase synthesis

GLP-1 has a natriuretic effect in the proximal renal tubules, the beneficial effects of GLP-1 and GLP-1RA may be related to the regulation of the RAAS (177)

4.3 Shared molecular pathways The following contents summarize several key pathways that affect both neuroinflammation and ferroptosis simultaneously

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