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Glutaredoxin-2 is required to control proton leak through uncoupling protein-3

Antioxid Redox Signal (2013) 18(15):190619

By default, that means its detoxifying the liver, which helps stave off conditions like fatty liver disease

As we get older, our levels of glutathione decrease, making us prone to age-related diseases

However, GSH levels were not completely abolished, which may be due to the presence of GCLC-expressing cells in the tumour microenvironment (Extended Data Fig