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The common link between diabetes mellitus and obesity-related issues is insulin resistance, which affects fat deposition in adipose tissue [7]

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Investigators are actively exploring its potential roles in cell recovery models , connective tissue signaling , and gastrointestinal system pathways under controlled laboratory conditions

In a cohort study involving 8,067 patients with T2D who participated in the National Health and Nutrition Examination Survey, low and high serum vitamin B12 levels were associated with a higher risk of cardiovascular disease mortality [69]

In ob/ob mice and Zucker rat models, it has consistently reduced fat mass, decreased epididymal and brown adipose tissue weight, and improved lipid profiles without affecting lean tissue or glucose homeostasis