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As a major determinant of the CIA targeting complex, MMS19 interacts with numerous target proteins and promotes the insertion of ISCs into them, including key enzymes in DNA synthesis (POLD1, PRIM2), DNA repair [XPD, DNA2 (DNA replication helicase/nuclease 2)], and telomere length regulation (RTEL1)

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Moreover, acetate, propionate, and butyrate contribute to glucose, cholesterol, and lipid metabolism, directly impacting hepatic energy levels (Den Besten et al., 2013)

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We then assessed genes encoding regulators of peptide transport, processing and presentation