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J., Parker, A

[] In state of obesity, the neuronal signals triggered by hepatic extracellular signal-regulated kinase (ERK) activation transmit to the brain through the afferent fibers of splanchnic nerves, after modulation of the signals in the brain, the efferent fibers of the vagal nerves release multiple neural factors, such as acetylcholine (ACh), pituitary adenylate cyclase activating polypeptide, and vasoactive intestinal polypeptide, and then, these neurotransmitters synergistically promote -cell proliferation through a FoxM1-dependent mechanism