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Importantly, overexpression of TrxR1 significantly reversed PLTXinduced GSH depletion, the decrease in GPx4 activity, and MDA accumulation, confirming the central role of TrxR1 in PLTX toxicity

Copper peptides (GHK-Cu) have been well-studied and are commonly used in aesthetics settings

PGC-1 is a transcriptional coactivator that interacts with several transcription factors to control the transcription of more than 150 genes encoding mitochondrial proteins involved in fatty acid oxidation, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS), the mitochondrial ribosomal machinery and membrane transport

To determine whether oxidation-reduction reactions involve glutathione or its anions, we created CASSCF(14, 13) models for geometric optimization, similar to those shown in Fig