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Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

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On the other hand, the JAK/STAT pathway, activated by cytokines such as IL-6 and interferons, contributes to BBB dysfunction by dimerizing STAT proteins upon activation which translocate to the nucleus, where they regulate the expression of genes involved in inflammation, cell survival, and barrier function

Recent findings suggest that endoplasmic reticulum (ER) stress signaling is closely correlated to ferritin formation, which is thought to be a promoter of UC