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Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation

246 In recent years, increasing evidence has shown that the PI3K/AKT signaling pathway is closely associated with the occurrence and development of UC and is also an important signaling pathway for targeted UC therapy

The NLRP3 inflammasome complex, which is composed of the immune receptor NLRP3 protein, ASC, and caspase-1, plays a key role in the classical pathway [122]