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Plasma iron concentrations are maintained at a low level (as complexes with transferrin), and this decreases substantially during the acute phase response to infection or other inflammatory stimuli (Saini et al., 2024)

doi: 10.1016/j.sdentj.2022.05.004 80 GasparC.DondersG

Besides, the IHC results of subcutaneous tumors, in situ implanted tumors and liver metastases of CRC in mice also confirmed the conclusion mentioned above

This is consistent with reports 30 that LNPs consisting of commercially available ionizable lipids, such as DLin-MC3-DMA, can activate the immune system, resulting in CARPA, an acute immunologic response that can lead to anaphylactic-like shock

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