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While these results have yet to be replicated in human clinical trials, the studys authors suggested that as Fragment 176-191 does not stimulate the production of IGF-1, it may be safer than human recombinant GH for the long-term treatment of OA [10]

Second, the respective study populations were quite different, with STEP 1 including a younger, healthier population with more women (73.1% of the semaglutide arm in STEP 1 versus 27.7% in SELECT) and higher mean BMI (37.8 kg m 2 versus 33.3 kg m 2 , respectively) 14,21

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