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MRP8 and the methotrexate efflux system A crucial property of methotrexate a potent dihydrofolate reductase inhibitor, is its susceptibility to polyglutamylation by the same enzyme that polyglutamylates physiological folates

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The binding of IL-1 and TNF- to the TLR4 receptor initiates a signaling cascade involving multiple proteins and ultimately activates NF-B, which drives the expression of pro-inflammatory cytokines (140)