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Redox thresholds determine the responsiveness of the system, as the release is triggered when intracellular glutathione (GSH) levels surpass a specific threshold, typically elevated in cancer cells

Promoter methylation and differential expression of -class glutathione S-transferase in endometrial carcinoma

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This decline exposes us to an increased risk of oxidative damage and age-related health issues

Additionally, inconsistent findings across studies are due to heterogeneity in sequencing platforms, CST classification methods and analytical pipelines