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ACKNOWLEDGEMENTS This review was financially supported by the National Natural Science Funds of China (81371247 and 81473749), the National Key Basic Research program of China (2013CB531906) and the Development Project of Shanghai Peak Disciplines-Integrated Chinese and Western Medicine

Studies indicate that osteocalcin mediates between bones and the pancreas in regulating glycemic status, promoting the proliferation of cells and insulin secretion through actions in the pancreas and adipocytes

The SS peptide family comprises oligopeptides that specifically target mitochondria, thereby safeguarding their function by stabilizing the inner mitochondrial membrane and inhibiting the formation of mtROS [157]

Lancet 356:469474 Sokol RJ, Twedt D, McKim JM Jr., Devereaux MW, Karrer FM, Kam I et al (1994) Oxidant injury to hepatic mitochondria in patients with Wilsons disease and Bedlington terriers with copper toxicosis

Wound Repair and Regeneration, 11(1), 19-24