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It can therefore be used as a basis for a possible hypothesis of new in vitro studies to compare the different molecules, for new in vivo studies and for the investigation of potential action mechanisms and applications for new drugs to combat diseases of the oral cavity

Additionally, as a hydrophilic molecule, DFO has a poor cell permeability and tends to remain in extracellular fluid, which may still limit its efficacy (Hanson et al., 2009

Nonetheless, studies conducted to date have established connections between lactylation modifications and cellular phenotype transformation, cellular metabolism, fibrosis and inflammation in PAH (Fig