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GPs may initiate treatment empirically in such cases, with diagnostic samples ideally taken beforehand where possible

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The five most upregulated genes in oligodendrocytes were HSPH1, HSPA1A, HSPB1, PTGES3 and HSP90AA1, while the five most downregulated genes were NAALADL2, MIR219-2, PPP2R2B, PDE1A and POLR2F (Fig