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The study by Oehler and colleagues in 2002 (34) examined pathologic changes of the synovial membrane in patients with early-stage OA and identified four histological patterns of OA-associated synoviopathy: (i) synovial lining hyperplasia, (ii) sublining and capsular fibrosis, (iii) macromolecular cartilage and bone debris (detritus-rich), and (iv) inflammatory manifestations and stromal vascularization ( Figure 2 ) (29, 3538)

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Biochemical features Biochemical features in ferroptosis involve iron accumulation, lipid peroxidation, generation of ROS, and depletion of glutathione peroxidase 4 (GPX4)

4,10 This theory was challenged when recent studies identified elevated concentrations of granulysin in the blister fluid of patients with SJS/TEN

Int J Fertil Steril 18:4553 Mridula S, Ram SB, Indra K, Sameeksha B, Pokar K, Susan IT (2020) PCOSKBR2: a database of genes, diseases, pathways, and networks associated with polycystic ovary syndrome