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According to epidemiological research, non-motor symptoms frequently occur decades before motor start, indicating early peripheral involvement

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doi: 10.1016/j.tcb.2022.05.005 117 ZhouWLiuMLiXZhangPLiJZhaoY

In the Bohr effect, the increase in the partial pressure of CO 2 directly shifts the dissociation curve of hemoglobinO 2 to the right and causes hemoglobin to release more O 2

KDM6A is located on the X chromosome and is known to escape the X-chromosome inactivation process, thereby providing females with two functional copies of the gene [118]