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doi: 10.1016/j.jbc.2021.101365 70 GnanapradeepanKBasuSBarnoudTBudina-KolometsAKungCPMurphyME

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Hence, radiotherapy induces the accumulation of oxidative substances within cells, leading to lipid peroxidation in cellular membranes, which disrupts membrane structural integrity and thereby triggers ferroptosis ( 3.2 Radiation reduces intracellular antioxidants Radiotherapy can cause the depletion of antioxidants within irradiated cells, thereby inducing ferroptosis