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AATD-associated liver disease (AATD-LD) is primarily caused by SERPINA1 protease inhibitor (Pi)*Z variants, of which the homozygous variant Pi*ZZ carries the greatest risk

10.1016/j.stemcr.2020.04.011 Stem Cell Rep

Currently, ruxolitinib, tofacitinib, and baricitinib are among the drugs considered for AA treatment, with only tofacitinib and ruxolitinib having received FDA approval [16]

For PDT, both IR820 and catalase were encapsulated in PLGA NPs to reach the MV3 melanoma cell line intravenously in the BALB/c nude mice at 68 weeks of age [196]