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CT scans offer detailed views of the bone structures, facilitating accurate assessments of lower limb alignment and notch geometry

Why this matters This approach supports the bodys ability to produce and regulate NAD internally, rather than delivering NAD itselfallowing physiologic control over how much NAD is generated based on cellular demand

Multimodal imaging has become a cornerstone, with clinical guidelines recommending structural neuroimaging in cognitively impaired individuals to assess medial temporal lobe atrophy and rule out other pathologies (177, 178)

By integrating renal targeting with multi-pathway regulation, nanotechnology provides a rational framework for translating the mechanistic advantages of natural products into clinically viable, disease-modifying therapies for ischemic AKI