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At 37C, therapeutic antibody binding increases the molecules ability to float within the membrane and - as known from traditional immunology - the antigen/antibody complex tends to accumulate at one pole of the cell

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We note that this enhancement did not fully restore efferocytosis to the level observed in M2 macrophages, suggesting that while the PKA-HSL axis is a critical component, other M2-specific factors also contribute to maximal efferocytosis function

rather, the mechanical act of injection is responsible

(Wang et al., 2018) details this: No study reported on clinical signs and symptoms of vitamin B12 deficiency (e.g