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Besides, there are also studies based on the integrated analysis of 1 H nuclear magnetic resonance metabolomics and dynamic 13 C isotope tracer technology showing that FGF-21 intervention effectively remodeled glucose metabolism in the brain, facilitating the conversion of [ 113 C]-glucose to the key neurotransmitter precursor and energy metabolism intermediate [ 313 C]-lactate while restoring metabolic homeostasis to the -aminobutyric acidergic system [219]