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This is a legitimate basis for clinical use but a different evidence tier than RCT data

These behavioral changes are associated with an increased volume of cerebellar lobe X and decreased microglial cell count at both anatomical and cellular levels (Maldonado-Ruiz et al., 2022)

The error has been fixed in the paper

Use in pregnancy, lactation and paediatric exposure has not been characterised in any published dataset, and no developmental-toxicology study has been formally reported

However, due to the positive experiences of hundreds of patients, taking B12 and biotin together is definitely worth a try if vitamin B12 alone leads to acne outbreaks