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Behavioral outcomes were assessed through the open field, three-chamber social interaction test and elevated plus maze, revealing improvements in repetitive behaviors, sociability, and anxiety-like response in vitamin E + VPA group (Alinaghi Langari et al., 2021)

Thus, pyruvate-induced competitive inhibition of -ketoglutarate will only contribute to the stability of HIF-1 but not to the functional activity of HIF-1 in non-hypoxic cells