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doi: 10.1016/S0092-8674(04)00400-3 60 WilkinsonDJPiaseckiMAthertonPJ

(2240:) geranylgeranyl diphosphate synthase 1 isoform B [Homo sapiens]

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Among other examples, the activation of the p16 INK4a /Rb and the p14 ARF /p53 signaling pathways is able to induce cellular senescence in response to time-dependent changes, including the accumulation of DNA damage (dAdda di Fagagna, 2008)