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The oxidative pathway is the primary mechanism under physiological conditions and is catalyzed by alcohol dehydrogenase (ADH) in the cytoplasm, which converts ethanol to acetaldehyde, a highly reactive and toxic intermediate [16]

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Herzog et al

10.1016/j.fct.2024.114474 [DOI] [PubMed] [Google Scholar] Penninx B

Upon activation by microbial PAMPs and other stress-related molecules, NLRP3 leads to the activation of caspase-1 followed by cleavage of pro-IL-1 into its active IL- form, which promotes further inflammatory signaling