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SKU: 10920204054
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Life (Basel)

In treated subjects, the mean estimated ALSFRS-R total score was 42.2 at baseline, 26.9 at month 12 and 11.5 at month 24, with a mean slope of 1.3, as compared to 43.4, 27.7 and 12.1, with a mean slope of 1.3 in not treated subjects (slope difference: 0.0

E., Rothwell, A

Notably, polygenic interactions (e.g., DEPDC5 , CHD2 variants), astrocytic calcium signaling aberrations, and mitochondrial metabolic deficits synergistically exacerbate network hyperexcitability