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Consequently, the challenge in the development of anti-cancer therapies is to produce pharmaceuticals that selectively target cancer cells while maintaining the ability of vital immune cells, like T cells, to function

Hepatology 192 TurchiJ

In this study, we present a comprehensive approach that integrates MVDA, xAI and flux-sum analysis within an enzyme capacity-constrained FBA (ecFBA) framework 33 to investigate the metabolic underpinnings of phenotypic drift in CHO cells during LTC (Fig