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In semaglutide, DPP-4 resistant GLP-1 is conjugated to a fatty acid chain of 18 carbon atoms, a natural ligand of albumin 93

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[DOI] [PMC free article] [PubMed] [Google Scholar] 294.Kaiser WJ, Sridharan H, Huang C, Mandal P, Upton JW, Gough PJ, Sehon CA, Marquis RW, Bertin J, Mocarski ES

Alexander Goldowsky, a gastroenterologist at Harvard-affiliated Beth Israel Deaconess Medical Center

It provides slower release compared to subcutaneous administration but may achieve higher local concentrations in the target area