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Specifically, in-house donors exhibited lower NAD + , NADH and NADP + levels (on average 3.2, 0.47 and 1.6 uM lower, respectively) but higher NADPH levels (on average 0.88 uM) compared to biobank samples (Supplementary Figure 2a)

While cytosolic and blood GSH and Cys biochemical species all experience depletion, the model predicts that a single exposure to doxorubicin only results in a minimal perturbation of the antioxidant defence system

Oxidized lipids block antigen cross-presentation by dendritic cells in cancer

Quantitative analysis confirmed that the inhibitory effect of aloe emodin is better than that of emodin, suggesting distinct mechanisms for each compound against breast cancer metastasis [503]