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Who May Benefit From B-Complex Support B-complex IV therapy may be considered for individuals with increased physiological demand or impaired absorption, including: Persistent fatigue or low energy High stress or demanding schedules Recovery from illness or prolonged inflammation Gastrointestinal conditions affecting absorption Individuals in Recovery from Alcohol Use Chronic alcohol use is associated with impaired absorption and increased depletion of several B vitaminsparticularly thiamine (B1), folate (B9), and B12

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However, low or absent MGMT may not always be a predictor of TMZ response it has been shown that approximately 35% of aggressive PRLomas or PRL-secreting PC that progressed despite TMZ therapy presented with absent MGMT expression (213)

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Acceleration Support scheme supported by funding from MRC IAA 2021 UCL MR/X502984/1